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Title: Altered Levels of Desaturation and omega-6 Fatty Acids in Breast Cancer Patients' Red Blood Cell Membranes
Authors: Amezaga, Javier; Ugartemendia, Gurutze; Larraioz, Aitziber and Bretana, Nerea; Iruretagoyena, Aizpea; Camba, Joana and Urruticoechea, Ander; Ferreri, Carla; Tueros, Itziar
Abstract: Red blood cell (RBC) membrane can reflect fatty acid (FA) contribution from diet and biosynthesis. In cancer, membrane FAs are involved in tumorigenesis and invasiveness, and are indicated as biomarkers to monitor the disease evolution as well as potential targets for therapies and nutritional strategies. The present study provides RBC membrane FA profiles in recently diagnosed breast cancer patients before starting chemotherapy treatment. Patients and controls were recruited, and their dietary habits were collected. FA lipidomic analysis of mature erythrocyte membrane phospholipids in blood samples was performed. Data were adjusted to correct for the effects of diet, body mass index (BMI), and age, revealing that patients showed lower levels of saturated fatty acids (SFA) and higher levels of monounsaturated fatty acid, cis-vaccenic (25\%) than controls, with consequent differences in desaturase enzymatic index ( increment 9 desaturase, -13.1\%). In the case of polyunsaturated fatty acids (PUFA), patients had higher values of omega-6 FA (C18:2 (+11.1\%); C20:4 (+7.4\%)). RBC membrane lipidomic analysis in breast cancer revealed that omega-6 pathways are favored. These results suggest new potential targets for treatments and better nutritional guidelines.
Keywords: arachidonic acid; breast cancer; linoleic acid; membrane lipidome; omega 6; red blood cell; SCD1; STEAROYL-COA DESATURASE-1; MULTIDRUG-RESISTANCE; LIPID-METABOLISM; INSIGHTS; GROWTH
Issue Date: 2020
Publisher: MDPI
Type: Article
DOI: 10.3390/metabo10110469
E-ISSN: 2218-1989
Funder: Basque Country Government (Department of the Environment, Regional Planning, Agriculture and Fisheries)
Centre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation under the grant agreement: TECNOMIFOOD project [CER-20191010]
Appears in Publication types:Artículos científicos

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