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dc.contributor.authorKonstantinidis, Ioannis-
dc.contributor.authorFirmino, Joana P.-
dc.contributor.authorInarra, Bruno-
dc.contributor.authorSan Martin, David-
dc.contributor.authorEstevez, Alicia-
dc.contributor.authorFernandes, Jorge M. O.-
dc.contributor.authorRuiz, Alberto-
dc.contributor.authorGisbert, Enric-
dc.description.abstractIn this study, we evaluated the replacement of dietary protein sources like fishmeal (FM) and plant proteins (PP) by Brewer's spent dry yeast (SDY) on the transcriptomic response (RNA-seq, NextSeq500 platform Illumina) in the liver, anterior-mid intestine, and head kidney in juveniles of gilthead sea bream (Sparus aurata). The inclusion of SDY at 30\% in the experimental diet (40\% crude protein, 16\% crude lipid) resulted in a reduction in FM (10\%) and PP (31.4\%) contents. Using RNA-seq, a total of 19.4 million raw reads per library were obtained, from whose 99.8\% of the sequenced data were retained. The alignment efficiency of uniquely mapped reads was 90.3, 89.5, and 89.8\% for head kidney, liver, and anterior-mid intestine, respectively. In total, 218 differentially expressed genes (DEGs) were identified among all tissues, out of which, 141 were up- and 77 down-regluated. The enrichment analysis of DEGs revealed that SDY had a modulatory effect on several processes related to host's immunity, oxygen's carrier capacity, steroidogenesis, metabolism, and digestion. It is of special relevance the immunomodulatory effects of the tested ingredient as data from RNA-seq showed from the three target tissues analyzed. These results indicated that this ingredient in addition to being considered as a sustainable raw material for replacing conventional protein sources in aquafeeds may also be considered as a functional ingredient due to its content in beta-glucans. The overall results of this study coupled with previous nutritional studies on this ingredient indicated the suitability of brewery's by-products like SDY in aquafeeds for carnivorous species like gilthead seabream, as well as supporting a circular bioeconomy model that reuses, recovers, and recycles resources instead of producing wastes.-
dc.subjectgilthead sea bream-
dc.subjectfunctional feed-
dc.subjectalternative dietary protein-
dc.subjectcircular feeds-
dc.titleBrewer's Spent Dry Yeast Modulates Immunity in Gilthead Sea Bream (Sparus aurata)-
dc.identifier.journalFRONTIERS IN MARINE SCIENCE-
dc.contributor.funderLIFE European Environment and Resource Efficiency Program, EU's financial instrument supporting environmental, nature conservation, and climate action projects throughout the EU [LIFE16ENV/ES/000160]-
dc.contributor.funderMinisterio de Economia, Industria y Competitividad (Government of Spain) [AGL2018-095653-R-I00]-
dc.contributor.funderErasmus C Programme of the European Union-
dc.contributor.funderAutonomous University of Barcelona (UAB) Exchange Programme Traineeship 2020-2021-
dc.contributor.funderMinisterio de Ciencia e Innovacion, Spain [PRE2019-091259, RTI2018-095653-RI00]-
Appears in Publication types:Artículos científicos

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