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dc.contributor.authorFerreri, Carla-
dc.contributor.authorSansone, Anna-
dc.contributor.authorChatgilialoglu, Chryssostomos; Ferreri, Rosaria-
dc.contributor.authorAmezaga, Javier-
dc.contributor.authorCaro, Mercedes-
dc.contributor.authorArranz, Sara-
dc.contributor.authorTueros, Itziar-
dc.date.accessioned2023-10-04T10:45:06Z-
dc.date.available2023-10-04T10:45:06Z-
dc.date.issued2022-
dc.identifierWOS:000808943600001-
dc.identifier.urihttp://dspace.azti.es/handle/24689/1610-
dc.description.abstractFatty acids have an important place in both biological and nutritional contexts and, from a clinical point of view, they have known consequences for diseases' onset and development, including cancer. The use of fatty acid-based food and nutraceuticals to support cancer therapy is a multidisciplinary subject, involving molecular and clinical research. Knowledge regarding polyunsaturated fatty acids essentiality/oxidizability and the role of lipogenesis-desaturase pathways for cell growth, as well as oxidative reactivity in cancer cells, are discussed, since they can drive the choice of fatty acids using their multiple roles to support antitumoral drug activity. The central role of membrane fatty acid composition is highlighted for the application of membrane lipid therapy. As fatty acids are also known as biomarkers of cancer onset and progression, the personalization of the fatty acid-based therapy is also possible, taking into account other important factors such as formulation, bioavailability and the distribution of the supplementation. A holistic approach emerges combining nutra- and pharma-strategies in an appropriate manner, to develop further knowledge and applications in cancer therapy.-
dc.language.isoEnglish-
dc.publisherMDPI-
dc.subjectanticancer strategy-
dc.subjectfatty acid signaling-
dc.subjectmembrane fatty acids-
dc.subjectmembrane lipidomics-
dc.subjectdietary fatty acids-
dc.subjectprecision nutraceuticals-
dc.subjectLIPID-PEROXIDATION PRODUCT-
dc.subjectDOCOSAHEXAENOIC ACID-
dc.subjectLUNG-CANCER-
dc.subjectEICOSAPENTAENOIC ACID-
dc.subjectKETOGENIC DIET-
dc.subjectCELL-DEATH-
dc.subjectMETABOLISM-
dc.subjectRECEPTOR-
dc.subjectBREAST-
dc.subjectMALONDIALDEHYDE-
dc.titleCritical Review on Fatty Acid-Based Food and Nutraceuticals as Supporting Therapy in Cancer-
dc.typeReview-
dc.identifier.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.format.volume23-
dc.contributor.funderFondazione Di Bella, Italy-
dc.contributor.funderCentre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation [CER-20191010]-
dc.contributor.funderAECC Scientific Foundation-
dc.identifier.e-issn1422-0067-
dc.identifier.doi10.3390/ijms23116030-
Appears in Publication types:Artículos científicos



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